Abstract
N-Phthaloyl 3-amino-3-arylpropionic acid analogs of thalidomide that are potent inhibitors of tumor necrosis factor-alpha are reported. These compounds were found to be potent inhibitors of phosphodiesterase 4.
MeSH terms
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3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
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Cyclic Nucleotide Phosphodiesterases, Type 4
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Humans
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Leukocytes, Mononuclear / drug effects
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Leukocytes, Mononuclear / metabolism
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Lipopolysaccharides / pharmacology
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Phosphodiesterase Inhibitors / chemistry
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Phosphodiesterase Inhibitors / pharmacology*
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Structure-Activity Relationship
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Thalidomide / analogs & derivatives*
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Thalidomide / chemistry
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Thalidomide / pharmacology
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Tumor Cells, Cultured
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
Substances
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Lipopolysaccharides
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Phosphodiesterase Inhibitors
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Tumor Necrosis Factor-alpha
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Thalidomide
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3',5'-Cyclic-AMP Phosphodiesterases
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Cyclic Nucleotide Phosphodiesterases, Type 4